Reconstructing mountainous landscape evolution throughout the Quaternary is challenging because of the poor long-term preservation of geomorphic records in a context of rapid surface dynamics and topographic rejuvenation. The Quaternary geomorphic evolution of the western European Alps has been strongly controlled by climatic oscillations between glacial and interglacial periods. Significant erosion and sediment remobilization during these glacial/interglacial cycles have left very few sedimentary archives to quantify the surface dynamics and paleo-environmental conditions within the mountain belt over the last hundreds of thousands of years. Alpine valleys within the periglacial zone are potential candidates to target long-term geological archives, since they may contain alluvial deposits that have been preserved from subsequent glaciations. In the Drac valley (French western Alps), three generations of paleo-valleys are preserved, each of which was filled with alluvial and lacustrine sediments in response to glacial damming downstream. The valleys were incised during subsequent times of glacial retreat, leading to the formation of epigenetic valleys. Detailed 3D mapping of the paleo-valleys was carried out using photogrammetric models to constrain their geometry. Mapping was combined with luminescence dating of alluvial deposits to reconstruct the temporal evolution of the Drac valley. This chronological framework, together with additional data from the literature, allowed us to quantitatively constrain the complex alluvial dynamics along the Drac river during the last ca. 230 ka. Poly-phased alluvial deposition occurred in the most recent paleo-valley between ca. 90 and 20 ka (i.e., from late MIS 5 to MIS 2) in a context of global climate cooling and major Alpine glaciation. Sediment infilling of the intermediate paleo-valley is dated at around 130 ka; i.e., during the late-glacial phase of the penultimate glaciation, at the abrupt warming transition between MIS 6 and MIS 5. Finally, the oldest paleo-valley was filled around 230 ka (during a sub-stage of MIS 7) probably in a cooling and glacial context. The overall alluviation pattern and chronology of the study area highlight the asynchronous and partially contrasting glacial dynamics between the different glacier systems (i.e., Drac, Bonne and Romanche/Isère glaciers) within the Ecrins-Pelvoux massif of the French western Alps.