<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03861401v1</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-21T17:51:33+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Liver organ-on-chip models for toxicity studies and risk assessment</title>
            <author role="aut">
              <persName>
                <forename type="first">Taha</forename>
                <surname>Messelmani</surname>
              </persName>
              <idno type="halauthorid">2649799-0</idno>
              <affiliation ref="#struct-537403"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lisa</forename>
                <surname>Morisseau</surname>
              </persName>
              <idno type="halauthorid">2649800-0</idno>
              <affiliation ref="#struct-537403"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yasuyuki</forename>
                <surname>Sakai</surname>
              </persName>
              <idno type="halauthorid">812138-0</idno>
              <affiliation ref="#struct-264150"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cécile</forename>
                <surname>Legallais</surname>
              </persName>
              <email type="md5">bf524198271e9233b292aa96219523fc</email>
              <email type="domain">utc.fr</email>
              <idno type="idhal" notation="string">cecile-legallais</idno>
              <idno type="idhal" notation="numeric">170850</idno>
              <idno type="halauthorid" notation="string">425700-170850</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8061-906X</idno>
              <idno type="IDREF">https://www.idref.fr/073387827</idno>
              <affiliation ref="#struct-537403"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Le Goff</surname>
              </persName>
              <email type="md5">7ccae3137d948ef9d03ca1af9cd0a03c</email>
              <email type="domain">utc.fr</email>
              <idno type="idhal" notation="string">anne-le-goff</idno>
              <idno type="idhal" notation="numeric">175451</idno>
              <idno type="halauthorid" notation="string">40559-175451</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8965-4892</idno>
              <idno type="IDREF">https://www.idref.fr/143032615</idno>
              <affiliation ref="#struct-537403"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eric</forename>
                <surname>Leclerc</surname>
              </persName>
              <email type="md5">77ac44586e76c4e1284ee40c042940e5</email>
              <email type="domain">utc.fr</email>
              <idno type="idhal" notation="string">cnrslec</idno>
              <idno type="idhal" notation="numeric">945746</idno>
              <idno type="halauthorid" notation="string">12957-945746</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7397-6205</idno>
              <affiliation ref="#struct-2208"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rachid</forename>
                <surname>Jellali</surname>
              </persName>
              <email type="md5">ccd84882247f7e48ca3b8b6b8f465321</email>
              <email type="domain">utc.fr</email>
              <idno type="idhal" notation="numeric">1104693</idno>
              <idno type="halauthorid" notation="string">688109-1104693</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0925-0298</idno>
              <affiliation ref="#struct-537403"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>RACHID</forename>
                <surname>JELLALI</surname>
              </persName>
              <email type="md5">ccd84882247f7e48ca3b8b6b8f465321</email>
              <email type="domain">utc.fr</email>
            </editor>
            <funder ref="#projanr-53748"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-28 20:58:43</date>
              <date type="whenModified">2026-04-27 12:26:02</date>
              <date type="whenReleased">2022-11-29 10:38:12</date>
              <date type="whenProduced">2022-06-28</date>
              <date type="whenEndEmbargoed">2023-05-29</date>
              <ref type="file" target="https://utc.hal.science/hal-03861401v1/document">
                <date notBefore="2023-05-29"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://utc.hal.science/hal-03861401v1/file/Manuscipt_R-LabChip-2022.pdf" id="file-3861401-3389243">
                <date notBefore="2023-05-29"/>
              </ref>
            </edition>
            <edition n="v2">
              <date type="whenSubmitted">2022-11-29 12:50:41</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="606078">
                <persName>
                  <forename>RACHID</forename>
                  <surname>JELLALI</surname>
                </persName>
                <email type="md5">ccd84882247f7e48ca3b8b6b8f465321</email>
                <email type="domain">utc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03861401</idno>
            <idno type="halUri">https://utc.hal.science/hal-03861401</idno>
            <idno type="halBibtex">messelmani:hal-03861401</idno>
            <idno type="halRefHtml">&lt;i&gt;Lab on a Chip&lt;/i&gt;, 2022, 22 (13), pp.2423-2450. &lt;a target="_blank" href="https://dx.doi.org/10.1039/d2lc00307d"&gt;&amp;#x27E8;10.1039/d2lc00307d&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Lab on a Chip, 2022, 22 (13), pp.2423-2450. &amp;#x27E8;10.1039/d2lc00307d&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3861401-3389243"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-COMPIEGNE">Université de Technologie de Compiègne</idno>
            <idno type="stamp" n="LIMMS">Laboratory for Integrated Micro Mechatronics Systems</idno>
            <idno type="stamp" n="BMBI" corresp="UNIV-COMPIEGNE">Laboratoire BMBI - Biomécanique et Bioingénierie</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Liver organ-on-chip models for toxicity studies and risk assessment</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Taha</forename>
                    <surname>Messelmani</surname>
                  </persName>
                  <idno type="halauthorid">2649799-0</idno>
                  <affiliation ref="#struct-537403"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lisa</forename>
                    <surname>Morisseau</surname>
                  </persName>
                  <idno type="halauthorid">2649800-0</idno>
                  <affiliation ref="#struct-537403"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yasuyuki</forename>
                    <surname>Sakai</surname>
                  </persName>
                  <idno type="halauthorid">812138-0</idno>
                  <affiliation ref="#struct-264150"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cécile</forename>
                    <surname>Legallais</surname>
                  </persName>
                  <email type="md5">bf524198271e9233b292aa96219523fc</email>
                  <email type="domain">utc.fr</email>
                  <idno type="idhal" notation="string">cecile-legallais</idno>
                  <idno type="idhal" notation="numeric">170850</idno>
                  <idno type="halauthorid" notation="string">425700-170850</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8061-906X</idno>
                  <idno type="IDREF">https://www.idref.fr/073387827</idno>
                  <affiliation ref="#struct-537403"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Le Goff</surname>
                  </persName>
                  <email type="md5">7ccae3137d948ef9d03ca1af9cd0a03c</email>
                  <email type="domain">utc.fr</email>
                  <idno type="idhal" notation="string">anne-le-goff</idno>
                  <idno type="idhal" notation="numeric">175451</idno>
                  <idno type="halauthorid" notation="string">40559-175451</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8965-4892</idno>
                  <idno type="IDREF">https://www.idref.fr/143032615</idno>
                  <affiliation ref="#struct-537403"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eric</forename>
                    <surname>Leclerc</surname>
                  </persName>
                  <email type="md5">77ac44586e76c4e1284ee40c042940e5</email>
                  <email type="domain">utc.fr</email>
                  <idno type="idhal" notation="string">cnrslec</idno>
                  <idno type="idhal" notation="numeric">945746</idno>
                  <idno type="halauthorid" notation="string">12957-945746</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7397-6205</idno>
                  <affiliation ref="#struct-2208"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rachid</forename>
                    <surname>Jellali</surname>
                  </persName>
                  <email type="md5">ccd84882247f7e48ca3b8b6b8f465321</email>
                  <email type="domain">utc.fr</email>
                  <idno type="idhal" notation="numeric">1104693</idno>
                  <idno type="halauthorid" notation="string">688109-1104693</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0925-0298</idno>
                  <affiliation ref="#struct-537403"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">16655</idno>
                <idno type="issn">1473-0197</idno>
                <idno type="eissn">1473-0189</idno>
                <title level="j">Lab on a Chip</title>
                <imprint>
                  <publisher>Royal Society of Chemistry</publisher>
                  <biblScope unit="volume">22</biblScope>
                  <biblScope unit="issue">13</biblScope>
                  <biblScope unit="pp">2423-2450</biblScope>
                  <date type="datePub">2022-06-28</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1039/d2lc00307d</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="spi">Engineering Sciences [physics]</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of functions in thebody, including homeostasis, synthesis of essential components, nutrient storage, and detoxification. As thecentre of metabolism for exogenous molecules, the liver is continuously exposed to a wide range ofcompounds, such as drugs, pesticides, and environmental pollutants. Most of these compounds can causehepatotoxicity and lead to severe and irreversible liver damage. To study the effects of chemicals and drugson the liver, most commonly, animal models or in vitro 2D cell cultures are used. However, data obtainedfrom animal models lose their relevance when extrapolated to the human metabolic situation and poseethical concerns, while 2D static cultures are poorly predictive of human in vivo metabolism and toxicity.As a result, there is a widespread need to develop relevant in vitro liver models for toxicology studies. Inrecent years, progress in tissue engineering, biomaterials, microfabrication, and cell biology has createdopportunities for more relevant in vitro models for toxicology studies. Of these models, the liver organ-onchip(OoC) has shown promising results by reproducing the in vivo behaviour of the cell/organ or a groupof organs, the controlled physiological micro-environment, and in vivo cellular metabolic responses. In thisreview, we discuss the development of liver organ-on-chip technology and its use in toxicity studies. First,we introduce the physiology of the liver and summarize the traditional experimental models for toxicitystudies. We then present liver OoC technology, including the general concept, materials used, cell sources,and different approaches. We review the prominent liver OoC and multi-OoC integrating the liver for drugand chemical toxicity studies. Finally, we conclude with the future challenges and directions for developingor improving liver OoC models.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-537403" status="VALID">
          <idno type="IdRef">282527842</idno>
          <idno type="RNSR">201220264D</idno>
          <idno type="ROR">https://ror.org/03yaydt41</idno>
          <orgName>Biomécanique et Bioingénierie</orgName>
          <orgName type="acronym">BMBI</orgName>
          <desc>
            <address>
              <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://bmbi.utc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93027" type="direct"/>
            <relation name="UMR7338 / UMR6600" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-264150" status="VALID">
          <orgName>Graduate School of Engineering [The University of Tokyo]</orgName>
          <orgName type="acronym">UTokyo | SOE</orgName>
          <desc>
            <address>
              <country key="JP"/>
            </address>
            <ref type="url">https://www.t.u-tokyo.ac.jp/en/soe/department/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-304304" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2208" status="VALID">
          <idno type="RNSR">200419757M</idno>
          <idno type="ROR">0059vr703</idno>
          <orgName>Laboratory for Integrated Micro Mechatronics Systems</orgName>
          <orgName type="acronym">LIMMS</orgName>
          <desc>
            <address>
              <addrLine>LIMMS/CNRS-IIS(UMI 2820)/ Institute of Industrial Science, University of Tokyo/ 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 Japan/</addrLine>
              <country key="JP"/>
            </address>
            <ref type="url">http://www.fujita3.iis.u-tokyo.ac.jp/~limms</ref>
          </desc>
          <listRelation>
            <relation active="#struct-304304" type="direct"/>
            <relation name="IRL2820 / UMI2820" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93027" status="VALID">
          <idno type="ROR">https://ror.org/04y5kwa70</idno>
          <orgName>Université de Technologie de Compiègne</orgName>
          <orgName type="acronym">UTC</orgName>
          <desc>
            <address>
              <addrLine>Université de Technologie de Compiègne - rue du Docteur Schweitzer- CS 60319 - 60203 Compiègne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.utc.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-304304" status="VALID">
          <idno type="IdRef">029909848</idno>
          <idno type="ROR">https://ror.org/057zh3y96</idno>
          <orgName>The University of Tokyo</orgName>
          <orgName type="acronym">UTokyo</orgName>
          <desc>
            <address>
              <addrLine>7 Chome-3-1 Hongo, Bunkyo, Tokyo 113-8654</addrLine>
              <country key="JP"/>
            </address>
            <ref type="url">https://www.u-tokyo.ac.jp/en/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-53748" status="VALID">
          <idno type="anr">ANR-19-CE19-0020</idno>
          <orgName>MIMLIVERonChip</orgName>
          <desc>Plateforme biomimétique Foie sur puce</desc>
          <date type="start">2019</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>