Article Dans Une Revue CardioVascular and Interventional Radiology Année : 2023

In Vitro Characteristics of a Cyanoacrylate/Water-Soluble Contrast Emulsion: Preliminary Data from Light Microscopy Approach

Kévin Guillen
Anne-Virginie Salsac
Pierre-Olivier Comby
Ludwig Serge Aho-Glele
  • Fonction : Auteur
Olivier Chevallier
Romaric Loffroy

Résumé

N-butyl cyanoacrylate (NBCA) is a lipophilic, permanent embolic glue that must be opacified for fluoroscopic guidance. Empirically, lipophilic Lipiodol Ultra Fluid® (LUF) has been added to produce a single-phase physically stable mixture. Varying the dilution ratio allows control of glue polymerization kinetics. LUF is far more costly than water-soluble iodinated contrast agents (ICAs). Our purpose was to evaluate whether a water-soluble nonionic iso-osmolar ICA could be used instead. We embolized both renal arteries of six swine using 1:3 NBCA–LUF or NBCA–iodixanol in 1:1, 1:3, and 1:7 ratios. We used both micro-computed tomography to assess the distality of glue penetration and indexed cast ratio and histology to assess distality, arterial obliteration, vessel-wall damage, and renal-parenchyma necrosis. Glue–LUF produced significantly greater indexed cast ratio and renal-artery ROI values and a significantly shorter cast-to-capsule distance. The injected volume was significantly greater with 1:7 iodixanol than with the other mixtures. No significant differences were found for histological evidence of artery obliteration, vessel-wall damage, or renal-parenchyma necrosis. This is the first study dealing with ICA alone as a contrast agent for cyanoacrylate embolization, compared to LUF. More research is needed to determine whether water-soluble nonionic iodinated agents can be used for human NBCA embolization given the good safety profile, availability, and low cost of ICA.
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Dates et versions

hal-04804763 , version 1 (03-12-2024)

Identifiants

Citer

Kévin Guillen, Anne-Virginie Salsac, Pierre-Olivier Comby, Ludwig Serge Aho-Glele, Olivier Chevallier, et al.. In Vitro Characteristics of a Cyanoacrylate/Water-Soluble Contrast Emulsion: Preliminary Data from Light Microscopy Approach. CardioVascular and Interventional Radiology, 2023, 46 (10), pp.1425 - 1427. ⟨10.1007/s00270-023-03533-8⟩. ⟨hal-04804763⟩
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